AAV siRNA Library

abm’s RNAi Expression System is now available in Adeno-Associated Virus format, combining the efficient expression of any siRNA with the advantage of non-integrating AAV for a new, powerful gene knockdown tool for gene therapy. The system is based on a unique convergent promoter design for greater efficiency of target gene knockdown without the need for a hair-pin loop structure commonly utilized in single promoter vectors, and includes a GFP reporter for monitoring transduction. abm offers a comprehensive library of human, mouse, and rat siRNAs in vector or pre-packaged AAV formats, available in multiple serotypes for tissue-specific knockdown.

Advantages of AAV siRNA:

Uses more potent 27-29 bp oligos than the traditional 19 or 21 bp oligos.
Convergent promoters to avoid hairpin loop structures, making sequencing and plasmid growth much easier.
GFP reporter for monitoring transfection or viral infection.
All constructs are available as a pooled set of 3 for improved gene knockdown.
Use AAV for low immunogenicity and no integration into the host genome.

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AAV siRNA Library

We offer siRNA AAV vectors and viruses for over 35000 human, mouse, and rat genes.

Product Information

Workflow
View our simplfied workflow with siRNA AAV vectors and viruses.
Vector Map
pAAV-siRNA-GFP vector map.
AAV Serotypes
We offer 9 AAV serotypes.

Documents

Top Publications

UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity.

Bi, X., et al.
eLife 7:e37993 (2018).

doi: 10.7554/eLife.37993.

Src-type tyrosine kinase p56lck is critical for thymic stromal lymphopoietin-induced allergic rhinitis.

Jeong, H.J., et al.
Clin Exp Allergy 48(7):875-889 (2018).

doi: 10.1111/cea.13167.

Carbon Monoxide Inhibits Islet Apoptosis via Induction of Autophagy.

Wang, H., et al.
Antioxid Redox Signal 28(14):1309-1322.

doi: 10.1089/ars.2016.6979.