Recombinant Human Artemin (ARTN) (E. coli)
Cat. No.
Z102355
Unit
Price
$205.00
Specifications
| Description | Artemin is a disulfide-linked member of the glial cell line-derived homodimeric neurotrophic factor (GDNF) family which all signal via a multicomponent receptor system composing of a high-affinity binding component (GFRα1-4) and a common signalling receptor tyrosine kinase (RET). Artemin prefers the receptor GFRα3-RET, but will use the others as an alternative. Artemin promotes the survival and growth of peripheral and central neurons, including dopaminergic neurons in the mid-brain; and plays an important role in the development of sensory and sympathetic neurons. |
| SKU | Z102355 |
| Unit quantity | 20 µg |
| Family | TGF-beta Super-family |
| Aliases | Enovin, Neublastin |
| Gene Symbol | ARTN |
| Gene ID | 9048 |
| Accession Number | Q5T4W7 |
| Source | E. coli |
| Species | Human (H. sapiens) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 12.2 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Lyophilized from a 0.2 µm filtered 10mM sodium citrate pH-4.5 and 25mM sodium chloride solution |
| Function | The ED50 as determined by its binding ability in a functional ELISA (using SH-SY5Y human neuroblastoma cells), is 4-16 ng/mL |
| Reconstitution | A quick spin of the vial followed by reconstitution in sterile distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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