Recombinant Human IL18BP
Cat. No.
Z101045
Unit
200 µg
Price
$660.00
Specifications
| Description | IL-18BP is a secreted protein that binds IL-18 with high affinity and prevents its interaction with the IL-18R. Different isoforms of IL-18BP have been demonstrated, four in human and two in the murine system, and biological activity is limited to particular isoforms. IL-18 binding protein is a constitutively expressed and secreted protein that resembles the extracellular domains of Ig-like receptors but has no transmembrane form. Because IL-18 is one of the early signals leading to IFN-gamma production by Th1 cells, blocking IL-18 activity by IL-18BP may be involved in down-modulation of the early phases of immune responses. |
| SKU | Z101045 |
| Unit quantity | 200 µg |
| Family | IL-1 Family |
| Aliases |
IL-18BP, Tadekinig-alfa Recombinant Human Interleukin-18 Binding Protein (IL18BP) |
| Gene Symbol | IL18BP |
| Gene ID | 10068 |
| Accession Number | O95998 |
| Source | HEK293 cells |
| Species | Human (H. sapiens) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 19 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method. |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Recombinant IL-18BP is supplied as an 0.2 μm filtered PBS solution. |
| Function | The activity of recombinant Interleukin-18 Binding Protein was determined by the ability to bind IL-18 in functional ELISA. |
| Reconstitution | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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