Recombinant Human IL2 (E. coli)
Cat. No.
Z100485
Unit
Price
$89.00
Specifications
Description A helical bundle of 4 α-helices, IL2 is an immunoregulatory cytokine that is expressed by CD4+/CD8+ T cells, γδ T cells, B cells, eosinophils and dendritic cells. IL2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. While Human IL2 shares 56% and 66% amino acid sequence identity with mouse and rat IL2, respectively only human and mouse IL2 exhibit cross-species activity. Characteristically, IL2 exerts both autocrine and paracrine activity on T cells. In a regulatory role, IL2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Recombinant Human IL2 is a non-glycosylated polypeptide that contains one intrachain disulfide bond.
SKU Z100485
Unit quantity 50 µg
Family Other Interleukins
Aliases IL-2, T-cell growth factor, TCGF
Recombinant Human Interleukin-2 (IL2)
Gene Symbol IL2
Gene ID 3558
Accession Number P60568
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 15 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method
Purity >95% as determined by SDS-PAGE
Formulation Lyophilized from a 0.2μm filtered solution in Tris and NaCL (pH 8.0)
Function The ED50 as determined by the dose dependent proliferation of human T cells was found to be less than 0.5 ng/mL equivalent to 0.8X10^4IU/μg as calibrated against International standard.
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
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