Recombinant Human IL2
Cat. No.
Z101235
Unit
50 µg
Price
$246.00
Specifications
| Description | IL-2 is produced mainly by T cells expressing the surface antigen CD4 following cell activation by mitogens or allogen. Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T cell proliferation. Th1 and Th2 effector T cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the optimal survival and function of memory cells. In a regulatory role, IL-2 is important for the development, survival, and function of regulatory T cells, it enhances Fas- mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Thus, in its dual and contrasting functions, IL-2 contributes to both the induction and the termination of inflammatory immune responses. |
| SKU | Z101235 |
| Unit quantity | 50 µg |
| Family | Other Interleukins |
| Aliases |
IL-2, T-cell growth factor, TCGF, INN=Aldesleukin Recombinant Human Interleukin-2 (IL2) |
| Gene Symbol | IL2 |
| Gene ID | 3558 |
| Accession Number | P60568 |
| Source | CHO cells |
| Species | Human (H. sapiens) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 15 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method. |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Recombinant Interleukin-2 was lyophilized from a 0.2 μm filtered concentrated (1.0 mg/mL) solution in PBS, pH 7.2. |
| Function | The ED(50) was determined by the dose dependent proliferation of murine CTLL-2 cells and was found to be less than 0.1 ng/mL, corresponding to a specific activity of > 2.0 x 10^7 units/mg. |
| Reconstitution | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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