Recombinant Human IL21 (E. coli)
Cat. No.
Z100495
Unit
Price
$284.00
Specifications
| Description | IL-21 stimulates proliferation of B cell stimulated by crosslinking of the CD40 antigen. It inhibits proliferation stimulated by IL-4 plus anti-IgM. IL-21 augments stimulation of the proliferation of naive CD45RA(+) but not memory CD45R0(+) T cells mediated by engagement of CD3. IL-21 stimulates the proliferation of bone marrow progenitor cells and the expression of the natural killer cell marker CD56 in the presence of IL-15. The Interleukin-21 receptor is closely related to human IL-2 beta receptor. The receptor contains a WSXWS motif in the extracellular region, typical of type 1 cytokine receptors. The receptor is expressed on natural killer cells, T cells, and B cell line. The functional signaling complex activates Janus kinases JAK1, JAK3, and the STAT proteins STAT1, and STAT3. |
| SKU | Z100495 |
| Unit quantity | 10 µg |
| Family | Other Interleukins |
| Aliases |
IL-21, Za11 Recombinant Human Interleukin-21 (IL21) |
| Gene Symbol | IL21 |
| Gene ID | 59067 |
| Accession Number | Q9HBE4 |
| Source | E. coli |
| Species | Human (H. sapiens) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 15 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method. |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Recombinant Interleukin-21 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5. |
| Function | The ED(50) was determined by the dose-dependent proliferation of HuT-78 Cells and was found to be <0.05ng/mL. |
| Reconstitution | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
STR
There are no STR for this product yet!
FAQs
There are no FAQs for this product yet!
References
There are no references for this product yet!
Controls and Related Product:
Other Cell Lines
Select Species:
African Green Monkey (C. aethiops)
(0)
Bat
(0)
Bat (Chiroptera)
(0)
Bee
(0)
Bottlenose Dolphin (Tursiops)
(0)
Cabbage Looper (T. ni)
(0)
Cat (Feline)
(0)
Cattle
(0)
Chicken (Galline)
(0)
Chinese Hamster (C. griseus)
(0)
Cow (Bovine)
(0)
Deer (Cervidae)
(0)
Dog (Canine)
(0)
Duck (Anas)
(0)
Duck (Anatidae)
(0)
E. coli
(0)
European Sea Bass
(0)
European Sea Bass (D. labrax)
(0)
Fall Armyworm (S. frugiperda)
(0)
Fish
(0)
Fly (D. melanogaster)
(0)
Frog (Xenopus)
(0)
Fruit Fly (D. melanogaster)
(0)
Gilthead Sea Bream (S. aurata)
(0)
Goat (Capra)
(0)
Golden Hamster (M. auratus)
(0)
Goose (Anatidae)
(0)
Green Monkey (C. aethiops)
(0)
Green Monkey (C. sabaeus)
(0)
Hamster (M. auratus)
(0)
Horse (Equine)
(0)
Human
(0)
Human (H. sapiens)
(0)
Insect
(0)
Insect (Insecta)
(0)
Killifish (F. heteroclitus)
(0)
Luciola italica
(0)
Marmoset (Primate)
(0)
Mink
(0)
Mink (N. vison)
(0)
Monkey (Primate)
(0)
Moth (S. frugiperda)
(0)
Mouse
(0)
Mouse (M. musculus)
(0)
N/A
(0)
Other
(0)
Photinus pyralis
(0)
Pig (Porcine)
(0)
Quail (Coturnix)
(0)
Rabbit (Leporidae)
(0)
Rabbit (Leporine)
(0)
Rainbow Trout (O. mykiss)
(0)
Rat (R. norvegicus)
(0)
Rat (Rattus)
(0)
Renilla reniformis
(0)
Roundworm (C. elegans)
(0)
Rous Sarcoma Virus (RSV)
(0)
SARS-CoV-2
(0)
Sheep (Ovine)
(0)
Sheep (Ovis)
(0)
Turtle
(0)
Turtle (Testudines)
(0)
Universal
(0)
Zebrafish (D. rerio)
(0)
Select Tissue:
0
(0)
Achilles Tendon
(0)
Adipose
(0)
Adrenal Gland
(0)
Adrenal Glands
(0)
Airway
(0)
Airway/Lung
(0)
Amniotic Sac
(0)
Antimesometrial Decidua
(0)
Antler
(0)
Ascites
(0)
Auditory
(0)
Bee Cell
(0)
Bile Duct
(0)
Bladder
(0)
Blood
(0)
Blood (Immune)
(0)
Blood Vessel
(0)
Bone
(0)
Bone Marrow
(0)
Brain
(0)
Breast
(0)
CAF, Tumor
(0)
Caput Epididymis
(0)
Cartilage
(0)
Cerebrospinal Fluid
(0)
Cervix
(0)
Colon
(0)
Connective Tissue
(0)
Cord Blood
(0)
Digestive
(0)
Digestive System
(0)
Ear
(0)
Embryo
(0)
embryonic
(0)
Endometria
(0)
Endometrium
(0)
Esophagus
(0)
Eye
(0)
Fallopian Tube
(0)
Fibroblast
(0)
Gingiva
(0)
Hair
(0)
Hair Follicle
(0)
Head/Neck
(0)
Heart
(0)
HeLa
(0)
Hepatocellular Carcinoma
(0)
Hippocampus
(0)
Intestinal
(0)
Intestine
(0)
Kidney
(0)
Kidney, Cortex/Proximal tubule
(0)
Labial Salivary Gland
(0)
Larynx
(0)
Liver
(0)
Lung
(0)
Lung Carcinoma
(0)
Lung, bronchus
(0)
Lymph
(0)
Lymph node
(0)
Lymphatic System
(0)
lymphoblast
(0)
Malignant melanoma
(0)
Mammary
(0)
Mesencephalic Tissue
(0)
Mesentery
(0)
Microglia
(0)
Mouth/Oral
(0)
Muscle
(0)
Myoblast
(0)
Nasal Mucosa
(0)
Nerve
(0)
Nervous System
(0)
Oesophageal
(0)
Oesophagus
(0)
Oral
(0)
Organ of Corti
(0)
Other
(0)
Ovary
(0)
Pancreas
(0)
Pancreatic
(0)
Parathyroid
(0)
Penile
(0)
Peripheral Blood
(0)
Peripheral Blood Mononuclear Cells
(0)
Peritoneal
(0)
Peritoneum
(0)
Pharynx
(0)
Pituitary
(0)
Pituitary Gland
(0)
Pituitary Tumor
(0)
Placenta
(0)
promyelocytic leukemia
(0)
Prostate
(0)
Prostate carcinoma
(0)
Renal
(0)
Reproductive
(0)
Reproductive System
(0)
Retina
(0)
Salivary Gland
(0)
Sciatic Nerve
(0)
Sertoli
(0)
Skeletal
(0)
Skeletal Muscle
(0)
Skin
(0)
Skin ; Keratinocytes
(0)
Small intestine
(0)
Smooth Muscle
(0)
Soft Tissue
(0)
Spinal
(0)
Spleen
(0)
Stem Cell
(0)
Stomach
(0)
Straitum
(0)
Sweat Gland
(0)
Tendon
(0)
Testes
(0)
Testis
(0)
Thymic
(0)
Thymus
(0)
Thyroid
(0)
Tongue
(0)
Tonsil
(0)
Trachea
(0)
Tumor
(0)
Umbilical Cord
(0)
Unknown
(0)
Urethra
(0)
Urinary Tract
(0)
Uterus
(0)
Uterus; endometrium
(0)
Vascular Endothelium
(0)
Ventral Mesencephalon
(0)
Vertebral Disc
(0)