Recombinant Human IL33 (E. coli)
Cat. No.
Z100535
Unit
Price
$89.00
Specifications
| Description | IL-33, a member of the IL-1 family, signals via a heterodimeric receptor complex consisting of ST2 and IL-1R accessory protein and triggers the activation of NF-B and all three MAPKs: p38, ERK1/2, and JNK1/2 in mast cells. IL-33 is expressed in multiple tissues and by several cell types such as dermal fibroblasts and small airway epithelial and bronchial smooth muscle cells. IL-33 activated IL-1-like signaling responses in mast cells and enhanced IL-5 and IL-13 production from murine Th2-polarized splenocytes. Moreover, it was found that both human and murine mast cells when stimulated in vitro with IL- 33 produced a wide spectrum of cytokines and chemokines. In addition, IL-33 enhanced IL-4-driven Th2 cell responses and acted as a selective chemoattractant for Th2 cell recruitment. |
| SKU | Z100535 |
| Unit quantity | 10 µg |
| Family | IL-1 Family |
| Aliases |
IL-33, Nuclear factor from high endothelial venules, Interleukin-1 family member 11, IL1F-11, C9orf26, NF-HEV Recombinant Human Interleukin-33 (IL33) |
| Gene Symbol | IL33 |
| Gene ID | 90865 |
| Accession Number | O95760 |
| Source | E. coli |
| Species | Human (H. sapiens) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 18 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method. |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Recombinant Interleukin-33 was lyophilized from 0.2 μm filtered 1.0 mg/mL in PBS buffer. |
| Function | The ED(50) was determined by the dose-dependent proliferation of murine D10S cells is ≤ 0.03 ng/mL. |
| Reconstitution | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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