Recombinant Human TNFRSF10B (E. coli)
Cat. No.
Z102247
Unit
Price
$363.00
Specifications
| Description | TNFRSF10B is a member of the TNFR superfamily and is a cell surface receptor that is involved in apoptosis. It contains an intracellular death domain and can be activated by binding to either membrane-anchored or soluble TRAIL/Apo2L. Diseases associated with TNFRSF10B include squamous cell carcinoma, head and neck and oral cavity cancer. Among its related pathways are Akt Signaling and Akt Signaling. It is closely related to TRAIL R1/DR4, sharing 55% amino acid sequence identity. |
| SKU | Z102247 |
| Unit quantity | 200 µg |
| Family | Other Growth Factors/Cytokines |
| Aliases | Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TRAIL receptor 2, TRAIL-R2, CD262, TNF-related apoptosis-inducing ligand receptor 2 |
| Gene Symbol | TNFRSF10B |
| Gene ID | 8795 |
| Accession Number | O14763 |
| Source | E. coli |
| Species | Human (H. sapiens) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 15 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Lyophilized from a solution in Tris and NaCl |
| Function | The ED(50) was determined by the dose-dependent proliferation of human umbilical vein endothelial cells and was found to be <0.2ng/mL. |
| Reconstitution | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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